Samantha Who (formerly known as Samantha Be Good, formerly known before that as Sam I Am) is the new comedy with Christina Applegate as someone who got bonked on the head, develops amnesia, and then slowly discovers that the person she used to be is not really the person she'd like to be.
I never really watched Married With Children, so I don't have any previous experience with Ms. Applegate, good or bad. I find her to be kind of the right balance between cute and annoying in this show, and the show itself is almost funny. I really like Jean Smart, also, no matter what she's in. I'm not sure how long they can drag out the amnesia thing though, because eventually she either recovers, learns everything about herself, or forges a new life and grows to accept it. There eventually has to be an end to the finding her in embarrassing comedic situations caused by her not remembering some crucial element from her past.
Also, I don't understand why developing amnesia after a bonk on the head is such a problem. I learned from Gilligan's Island that it's easily cured by applying another bonk to the head.