Chuck is the spy comedy about a guy who somehow gets the government's deepest darkest secrets downloaded straight to his brain, leaving the government to alternately attempt to destroy and protect him.
It's one of two shows this season that feature prominent nerd scenarios (the other being Big Bang Theory), and Chuck is definitely the less insulting of the two.
It's funny enough that I'll definitely watch it again. But what was most notable to me about the pilot was that the female lead (the cute blond CIA agent) had not one, but two extended scenes in her underwear. This indicates to me that the producers are very acutely aware of their target demographic, which does bode well for the long term hopes for the show.